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1V209
CAS No. 1062444-54-5
1V209 ( TLR7 agonist T7 )
产品货号. M21560 CAS No. 1062444-54-5
1V209 是一种 Toll 样受体 7 (TLR7) 激动剂，具有抗肿瘤作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥472 | 有现货 |
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| 10MG | ￥752 | 有现货 |
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| 25MG | ￥1516 | 有现货 |
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| 50MG | ￥2213 | 有现货 |
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| 100MG | ￥3033 | 有现货 |
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| 200MG | ￥4140 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥373 | 有现货 |
|
生物学信息
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产品名称1V209
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述1V209 是一种 Toll 样受体 7 (TLR7) 激动剂，具有抗肿瘤作用。
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产品描述1V209 ?is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
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体外实验1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells. 1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells.
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体内实验The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration.
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同义词TLR7 agonist T7
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通路Immunology/Inflammation
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靶点TLR
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受体TLR7
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研究领域——
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适应症——
化学信息
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CAS Number1062444-54-5
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分子量359.34
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分子式C16H17N5O5
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纯度>98% (HPLC)
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溶解度DMSO:83.33 mg/mL (231.90 mM; Need ultrasonic)
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SMILESCOCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(cc3)C(O)=O)c2n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α?Mannose as Adjuvants[J]. Bioconjugate Chemistry 2019 30(11):2811-2821.
