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Visnagin
CAS No. 82-57-5
Visnagin ( —— )
产品货号. M21531 CAS No. 82-57-5
Visnagin 具有急性低血压、抗炎和神经保护作用，它通过调节线粒体苹果酸脱氢酶来预防阿霉素诱导的心肌病。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥126 | 有现货 |
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| 5MG | ￥183 | 有现货 |
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| 10MG | ￥252 | 有现货 |
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| 25MG | ￥388 | 有现货 |
|
| 50MG | ￥574 | 有现货 |
|
| 100MG | ￥794 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥185 | 有现货 |
|
生物学信息
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产品名称Visnagin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Visnagin 具有急性低血压、抗炎和神经保护作用，它通过调节线粒体苹果酸脱氢酶来预防阿霉素诱导的心肌病。
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产品描述Visnagin has acute hypotensive anti-inflammatory and neuroprotective effects it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.
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体外实验Visnagin (10 μM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells. Visnagin (10 μM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 μM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner.
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体内实验Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g).Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number82-57-5
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分子量230.22
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分子式C13H10O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (217.18 mM)
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SMILESCC(Oc1cc(occ2)c2c(OC)c11)=CC1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Radim Vrzal et al. Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells. PLoS One. 2013 Sep 19;8(9):e74917.
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