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Securinine
CAS No. 5610-40-2
Securinine ( (-)-Securinine )
产品货号. M21463 CAS No. 5610-40-2
(-)-Securinine 是植物来源的生物碱，也是 GABAA 受体拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥635 | 有现货 |
|
| 10MG | ￥918 | 有现货 |
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| 25MG | ￥1460 | 有现货 |
|
| 50MG | ￥2316 | 有现货 |
|
| 100MG | ￥3384 | 有现货 |
|
| 200MG | ￥4842 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Securinine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(-)-Securinine 是植物来源的生物碱，也是 GABAA 受体拮抗剂。
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产品描述(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.(In Vitro):(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.(In Vivo):In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
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体外实验(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily(TNFRSF) genes in the cells stimulated with (-)-Securinine.
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体内实验In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
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同义词(-)-Securinine
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通路Others
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靶点Other Targets
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受体GABAA
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研究领域——
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适应症——
化学信息
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CAS Number5610-40-2
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分子量217.26
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分子式C13H15NO2
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纯度>98% (HPLC)
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溶解度DMSO:2 mg/mL (9.21 mM)
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SMILESO=C1O[C@](C2)([C@@H](CCCC3)N3[C@@H]2C=C2)C2=C1
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化学全称(6S11aR11bS)-9101111a-tetrahydro-8H-611b-methanofuro[23-c]pyrido[12-a]azepin-2(6H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Stefanowicz-Hajduk J et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11(10):e0165372.
产品手册
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