Diallyl Trisulfide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

二烯丙基三硫化物是大蒜中发现的一种有机多硫化物，可作为 H2S 供体。

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Cell Cytotoxicity Assay Cell Line:A549 Concentration:75 μM, 93.75 μM, 125 μM, 125 μM, 187.5 μM, 250 μM, 375 μM, 500 μM Incubation Time:48 h Result:Was not cytotoxic to A549 cells.Cell Viability Assay Cell Line:A549 Concentration:25 μM, 50 μM, 100 μM Incubation Time: 24 h Result:Significantly inhibited cell activity in a dose-dependent manner. Western Blot Analysis Cell Line:A549 Concentration:25 μM, 50 μM, 100 μM Incubation Time:24 h; 48 h; 72 h Result:Significantly reduced the expression of Bcl-2 protein at a dose of 100 μM for 48 h.significantly increased the expression of Bax protein.RT-PCRCell Line:A549 Concentration:100 μM Incubation Time:48 h Result:Increased the mRNA expression of caspase-3, -8, and -9.Significantly increased the expression of Bax mRNA.Real Time qPCR Cell Line:A549 Concentration:375 μM Incubation Time:24 h, 48 h Result:Increased the expression of antiviral factors RIG-I, IRF-3 and IFN-β.

Animal Model:Kunming mouse model of inflammation induced by naphthaleneDosage:20 mg/kg, 40 mg/kg, 80 mg/kg Administration:Oral gavage (p.o.); Single dose. Before naphthalene treatment (100 mg/kg; p.o., single dose)Result:Inhibited the production of serum nitric oxide (NO) and pulmonary myeloperoxidase (MPO).Significantly reduced the area of inflammatory cell infiltration induced by naphthalene and alleviated lung injury in mice.Animal Model:BABL/c mice model infected with H9N2 AIV Dosage:30 mg/kg Administration:Intraperitoneal injection (i.p.); Once daily for two weeks Result:Reduced the severity of pulmonary edema.Significantly reduced viral load in mouse lungs.

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Others

Other Targets

Others

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2050-87-5

178.3

C6H10S3

>98% (HPLC)

DMSO:5mg/ml(28.04mM)

C=CCSSSCC=C

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(-20℃)

With Ice Pack

≥ 2 years