AUDA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AUDA 是 sEH 的抑制剂（对小鼠和人类酶的 IC50 值分别为 18 和 69 nM）。

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).

AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs. Cell Proliferation AssayCell Line:Vascular smooth muscle cell (VSMC)Concentration:0.3, 1, 3, 10 μg/mLIncubation Time:48 hoursResult:Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF. Western Blot AnalysisCell Line:VSMC Concentration:1, 3, 10, 30 μg/mL Incubation Time:30 minResult:Dose-dependently upregulated COX-2 expression.

AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels. Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g) Dosage:10 mg/kg Administration:i.p.; 14 days Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.

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Others

Other Targets

sEH

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479413-70-2

392.6

C23H40N2O3

>98% (HPLC)

DMSO:1mg/ml(2.55mM)

O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2

12-[(Adamantan-1-ylcarbamoyl)amino]dodecanoic acid

(-20℃)

With Ice Pack

≥ 2 years