FK962

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FK962 是一种生长抑素释放增强剂，具有认知增强作用。

FK962 is an somatostatin release enhancer exerts cognitive-enhancing actions.(In Vitro):FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.(In Vivo):FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.

FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.

FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease. Animal Model:Male Lister Hooded rats, weighing approximately 270-300 Dosage:0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration:Administered i.p.Result:Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.

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Others

Other Targets

Somatostatin release

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283167-06-6

264.3

C14H17FN2O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (945.89 mM)

CC(=O)N1CCC(NC(=O)c2ccc(F)cc2)CC1

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(-20℃)

With Ice Pack

≥ 2 years