FGH-10019

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FGH-10019 是一种新型甾醇调节元件结合蛋白 (SREBP) 抑制剂 (IC50:1 μM)。

FGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).

Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC50 of fatostatin (appr 10 μM).

FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice.

——

Others

Other Targets

SREBPs

——

——

1046045-61-7

373.49

C18H19N3O2S2

>98% (HPLC)

DMSO:38 mg/mL (101.74 mM)

CCCc1cc(-c2nc(-c3ccc(NS(C)(=O)=O)cc3)cs2)ccn1

——

(-20℃)

With Ice Pack

≥ 2 years