Piperaquine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Piperaquine 是一种双喹啉化合物，可抑制来自疟疾感染患者的恶性疟原虫分离株的离体生长，IC50 范围为 11.8-217.3 nM。

Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.

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Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.

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Microbiology/Virology

Parasite

Parasite

Infection

Falciparum malaria; Vivax malaria

4085-31-8

535.5

C29H32Cl2N6

>98% (HPLC)

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Clc1ccc2c(N3CCN(CCCN4CCN(c5ccnc6cc(Cl)ccc56)CC4)CC3)ccnc2c1

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(-20℃)

With Ice Pack

≥ 2 years