Teriflunomide(b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

特立氟米特是来氟米特的主要活性代谢物，来氟米特是一种已批准的治疗类风湿关节炎和多发性硬化症的化合物。

Teriflunomide is the principal active metabolite of leflunomide?an approved therapy for rheumatoid arthritis and?multiple sclerosis.(In Vitro):Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.(In Vivo):Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity.

Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.

Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity.

A 77-1726

Others

Other Targets

Others

Neurological Disease

multiple sclerosis (MS)

163451-81-8

270.21

C12H9F3N2O2

>98% (HPLC)

DMSO:26 mg/mL (96.22 mM)

C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1

——

(-20℃)

With Ice Pack

≥ 2 years