3-Guanidinopropionic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-胍基丙酸是一种肌酸类似物，可改变骨骼肌能量消耗。它降低细胞 ATP、肌酸和磷酸肌酸水平，并刺激 AMP 激活蛋白激酶 (AMPK)，激活 PPARγ 共激活剂 1α (PGC-1α)。

3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure.?It reduces cellular ATP creatine and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK) activating PPARγ coactivator 1α (PGC-1α).

Ompenaclid (RGX-202; 10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia.

Ompenaclid (RGX-202; 800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice.Ompenaclid (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice. Animal Model:UN-KPC-961 pancreatic tumor-bearing B6129SF1/J miceDosage:800 mg/kg Administration:p.o. for 35 days Result:Suppressed tumoral d3-creatine import by 50% at 800 mg/kg.Animal Model:6- to 9-week-old C57BL/6J male wild-type mice Dosage:100, 250, 500 mg/KG in sterile 0.9% NaCl Administration:p.o. for 35 days Result:Inhibited tissue uptake of d3-creatine in a dose-dependent manner by up to 75% at 500 mg/kg.

β-GPA

Others

Other Targets

Others

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353-09-3

131.13

C4H9N3O2?

>98% (HPLC)

In Vitro:?H2O : ≥ 50 mg/mL (381.27 mM)D)

N=C(N)NCCC(=O)O

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(-20℃)

With Ice Pack

≥ 2 years