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AX20017
CAS No. 329221-38-7
AX20017 ( —— )
产品货号. M20738 CAS No. 329221-38-7
AX20017 是一种小分子蛋白激酶 G (PknG) 抑制剂 (IC50 : 0.39 μM)。它通过阻止结核分枝杆菌的增殖发挥作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥236 | 有现货 |
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| 10MG | ￥330 | 有现货 |
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| 25MG | ￥647 | 有现货 |
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| 50MG | ￥1032 | 有现货 |
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| 100MG | ￥1494 | 有现货 |
|
| 200MG | ￥2223 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥316 | 有现货 |
|
生物学信息
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产品名称AX20017
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AX20017 是一种小分子蛋白激酶 G (PknG) 抑制剂 (IC50 : 0.39 μM)。它通过阻止结核分枝杆菌的增殖发挥作用。
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产品描述AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
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体外实验The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体PknG
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研究领域——
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适应症——
化学信息
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CAS Number329221-38-7
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分子量264.34
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分子式C13H16N2O2S
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纯度>98% (HPLC)
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溶解度DMSO:32 mg/mL (121.06 mM)
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SMILESNC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
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化学全称2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Scherr N Honnappa S Kunz G et al. Structural basis for the specific inhibition of protein kinase G a virulence factor of Mycobacterium tuberculosis[J]. Proceedings of the National Academy of Sciences 2007 104(29):12151-12156.
产品手册
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