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Valorphin
CAS No. 144313-54-2
Valorphin ( Valorphin TFAsalt )
产品货号. M20720 CAS No. 144313-54-2
Valorphin 具有阿片类镇痛活性，与大鼠 mu-阿片受体结合，IC50 为 14 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥663 | 有现货 |
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| 5MG | ￥947 | 有现货 |
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| 10MG | ￥1422 | 有现货 |
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| 25MG | ￥2778 | 有现货 |
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| 50MG | ￥4174 | 有现货 |
|
| 100MG | ￥6054 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Valorphin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Valorphin 具有阿片类镇痛活性，与大鼠 mu-阿片受体结合，IC50 为 14 nM。
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产品描述Valorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
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体外实验Valorphin is a derivative of dihydrovaltrate with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM. Valorphin has low affinity for δ-opioid receptor (IC50, 200 nM) and shows no affinity for κ receptor (IC50, >10 μM). Valorphin (>10 μM) decreases spontaneous firing rate of cerebellar rat Purkinje cells. Valorphin (1 μM) treatment 48 h prior to 0.1 μM epirubicin, or 0.1 μM vincristine, or 0.05 μM vincristine, causes 100% tumor cell death.
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体内实验Valorphin exhibits pronounced analgesic activity in mice, rats and rhesus monkeys via s.c, with ED50s of ≤5.2 mg/kg, but barely active after oral administration. Valorphin (1 mg/kg) causes 42% of tumor growth inhibition in female BLRB mice bearing syngeneic mammary carcinoma cells.
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同义词Valorphin TFAsalt
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体Opioid Receptor
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研究领域——
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适应症——
化学信息
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CAS Number144313-54-2
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分子量893
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分子式C44H60N8O12
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Blishchenko E Y Sazonova O V Kalinina O A et al. Antitumor effect of valorphin in vitro and in vivo: Combined action with cytostatic drugs[J]. Cancer Biology & Therapy 2005 4(1):125-131.
产品手册
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