BRD9539

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BRD9539 是常染色质组蛋白甲基转移酶 2 (EHMT2)（也称为 G9a）的抑制剂，IC50 值为 6.3 μM。

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.

BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.

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Chromatin/Epigenetic

Histone Demethylase

G9a

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1374601-41-8

399.44

C24H21N3O3

>98% (HPLC)

DMSO:35 mg/mL (87.62 mM)

OC(=O)c1ccc2n(CCCc3ccccc3)c(NC(=O)c3ccccc3)nc2c1

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(-20℃)

With Ice Pack

≥ 2 years