Nicotinamide riboside chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯化烟酰胺核苷，也称为 NR 和 SRT647，是维生素 B3 的吡啶核苷形式，可作为烟酰胺腺嘌呤二核苷酸或 NAD+ 的前体。

Nicotinamide riboside chloride also known as NR and SRT647 is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19. Western Blot Analysis Cell Line:HEK293T cellsConcentration:0.5 nMIncubation Time:24 hoursResult:Reduced the acetylation status of Ndufa9 and SOD2.

Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner. Animal Model:10-week-old C57Bl/6J mice Dosage:400 mg/kg Administration:PO; daily; for 16 weeks Result:Increased plasma and intracellular NAD+ content in a tissue-specific manner.

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Chromatin/Epigenetic

Sirtuin

SIRT1/3

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23111-00-4

290.7

C11H15ClN2O5

>98% (HPLC)

H2O:125 mg/mL (430.00 mM; Need ultrasonic);DMSO:50 mg/mL (172.00 mM; Need ultrasonic)

[Cl-].NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years