Indinavir sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indinavir 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶，IC50 值为 0.41 nM，Ki 值为 0.24 nM。

Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.

Cell Viability Assay Cell Line:PBMCs (from healthy and HIV-infected volunteers)Concentration:0-50 μMIncubation Time:18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)Result:Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.Resulted in dose-dependent reduction of lymphoproliferative responses.Cell Invasion Assay Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:5 days Result:Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.Western Blot Analysis Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:48 h Result:Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.

Animal Model:Nude mice(s.c. into Huh7 and SK-HEP-1 cells).Dosage:70 mg/kg Administration:Oral gavage; once a day for 3 weeks. Result:Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.

MK-639 sulfate | L735524 sulfate

Microbiology/Virology

HIV

HIV Protease

Inflammation/Immunology

HIV infection.

157810-81-6

711.87

C36H49N5O8S

>98% (HPLC)

DMSO:100 mg/mL (140.48 mM)

OS(O)(=O)=O.CC(C)(C)NC(=O)C1CN(Cc2cccnc2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12

(S)-1-((2S4R)-4-benzyl-2-hydroxy-5-(((1S2R)-2-hydroxy-23-dihydro-1H-inden-1-yl)amino)-5-oxopentyl)-N-(tert-butyl)-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate

(-20℃)

With Ice Pack

≥ 2 years