HYOSCINE HYDROCHLORIDE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Scopolamine hydrochloride 是一种非选择性和高亲和力的毒蕈碱（muscarinic） 拮抗剂。Scopolamine hydrochloride 可通过血脑屏障。Scopolamine hydrochloride 可逆地抑制 5-HT3 受体，IC50 为 2.09 μM。Scopolamine hydrochloride 可通过改变胆碱能系统诱导阿尔茨海默病样病理。

HYOSCINE HYDROCHLORIDE versus placebo in preventing motion sickness has been shown to be effective.

Scopolamine blocks nicotinic acetylcholine receptors (IC50=928 μM) and increases the expression of α7 nACh receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17±0.24 (Ki=6.76 μM). Concentration-dependent competition of fluorescently labeled form of granisetron (G-FL) with Scopolamine gives an average pKi of 5.31±0.09 (Ki=4.90 μM).Scopolamine blocks muscarinic receptors and induces a cognitive deficit.Scopolamine (0.1-3 mM; for 24 hours) induces cytotoxicity, ROS generation and apoptosis of SH-SY5Y cells.Cell Viability Assay Cell Line:Human neuroblastoma SH-SY5Y cell line Concentration:0.1-3 mM (usually 2 mM) Incubation Time:24 hours Result:Exposure to 1-3 mM for 24 hours significantly decreased human neuroblastoma SH-SY5Y cell viability in a dose-dependent manner. In all subsequent experiments, 2 M resulted in 50.6±2.2% loss in cell viability.

Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain. Animal Model:Naive male Swiss mice weighing 20-25 Dosage:1mg/kg Administration: Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest Result:In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning.

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Others

Other Targets

Others

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55-16-3

339.8

C17H22ClNO4?

>98% (HPLC)

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Cl.[H][C@@]12O[C@]1([H])[C@H]1C[C@H](C[C@@H]2N1C)OC(=O)[C@H](CO)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years