Kavain

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kavain 是一种从卡瓦植物 Piper methysticum 中提取的化合物，被发现通过调节 NF-kB 和 LITAF 等转录因子参与人和小鼠细胞中 TNF-α 的表达。

Kavain a compound extracted from the Kava plant Piper methysticum is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.

Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site.

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Others

Other Targets

Others

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3155-48-4

230.26

C14H14O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (217.15 mM)

COC1=CC(=O)OC(C1)\C=C\c1ccccc1

(E)-4-methoxy-6-styryl-56-dihydro-2H-pyran-2-one

(-20℃)

With Ice Pack

≥ 2 years