SN6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SN 6 是一种选择性 Na+/Ca2+ 交换器 (NCX) 抑制剂（NCX1 的 IC50：2.9 μM，NCX2：16 μM，NCX3：8.6 μM）。

SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor?(IC50s of NCX1: 2.9 μM NCX2: 16 μM NCX3: 8.6 μM)

SN 6 is a selective Na+/Ca2+ exchanger inhibitor, which inhibits the initial rate of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC50 of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na+i-dependent 45Ca2+ uptake into Na+-loaded sarcolemmal vesicles in a dose dependent manner (IC50, 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants. SN 6 (1-30 μM) suppresses the bidirectional outward and inward INCX in a concentration-dependent manner, with IC50 values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (INCX) in a [Na+]i concentration-dependent manner, with IC50 values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na+]i, respectively. SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC50 value of 0.63 ± 0.15 μM in NCX1 transfectants.

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Others

Other Targets

NCX 1|NCX2|NCX3

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415697-08-4

402.47

C20H22N2O5S

>98% (HPLC)

DMSO:62.5 mg/mL (155.29 mM);Water:Insoluble

CCOC(=O)C1CSC(Cc2ccc(OCc3ccc(cc3)[N+]([O-])=O)cc2)N1

Ethyl 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-13-thiazolidine-4-carboxylate

(-20℃)

With Ice Pack

≥ 2 years