3-methyl toxoflavin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-methyltoxoflavin 是蛋白质二硫键异构酶 (PDI) 的有效抑制剂，其 IC50 值为 170 nM。

3-methyltoxoflavin is an effective inhibitor of protein disulfide isomerase (PDI) and its IC50 value is 170 nM.

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis.

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3-methyltoxoflavin

Others

Other Targets

protein disulfide isomerases

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32502-62-8

207.19

C8H9N5O2

>98% (HPLC)

DMSO:150 mg/mL (723.97 mM)

Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1

136-Trimethyl-pyrimido[54-e]-124-triazine-57(1H6H)-dione

(-20℃)

With Ice Pack

≥ 2 years