VK3-OCH3 ( 2-[(2-Methoxy)ethylthio]-3-methyl-14-na )

产品货号. M20174 CAS No. 255906-59-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

VK3-OCH3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

2-[(2-甲氧基)乙硫基]-3-methyl-1,4-na 是一种通过血红素加氧酶 (HO-1) 相关机制的选择性抗肿瘤剂；维生素 K3 类似物。
产品描述

2-[(2-Methoxy)ethylthio]-3-methyl-14-na is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.
体外实验

VK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 μM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively.VK3-OCH3 (1, 3, 10 μM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells.VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells.VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin.
体内实验

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同义词

2-[(2-Methoxy)ethylthio]-3-methyl-14-na
通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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计算器

产品手册

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