Aranidipine ( MPC1304 )

产品货号. M20129 CAS No. 86780-90-7

Aranidipine (MPC1304) 是一种钙通道拮抗剂，具有有效且持久的抗高血压作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥236	有现货
10MG	￥377	有现货
25MG	￥686	有现货
50MG	￥1107	有现货
100MG	￥1602	有现货
200MG	￥2367	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Aranidipine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Aranidipine (MPC1304) 是一种钙通道拮抗剂，具有有效且持久的抗高血压作用。
产品描述

Aranidipine (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.(In Vivo):Aranidipine (MPC-1304) is a new Ca2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in Bmax values for specific [3H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The Bmax values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The Bmax values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The Kd values for myocardial [3H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.
体外实验

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体内实验

Aranidipine (MPC-1304) is a new Ca2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in Bmax values for specific [3H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The Bmax values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The Bmax values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The Kd values for myocardial [3H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.
同义词

MPC1304
通路

GPCR/G Protein
靶点

Calcium Channel
受体

Calcium Channel
研究领域

Cardiovascular Disease
适应症

Angina pectoris and high blood pressure

化学信息

CAS Number

86780-90-7
分子量

388.37
分子式

C19H20N2O7
纯度

>98% (HPLC)
溶解度

DMSO:10 mM
SMILES

COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OCC(C)=O
化学全称

(+-)-Acetonyl methyl 14-dihydro-26-dimethyl-4-(o-nitrophenyl)-35-pyridinedicarboxylate

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Masumiya H et al. Inhibition of T-type and L-type Ca(2+) currents by aranidipine a novel dihydropyridine Ca(2+) antagonist. Pharmacology. 2000 Aug;61(2):57-61.

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