Loreclezole ( —— )

产品货号. M20110 CAS No. 117857-45-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Loreclezole
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Loreclezole 是一种选择性 GABAA 受体调节剂，可作为含有 β2 或 β3 亚基的受体的正变构调节剂。
产品描述

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
体外实验

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体内实验

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test. Animal Model:Adult male Lister Hooded rats.Dosage:10, 25, 50 or 75 mg/kg.Administration:IP, 60 min before measurement of seizure threshold.Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
同义词

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通路

Others
靶点

Other Targets
受体

GABAA
研究领域

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适应症

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1.Donnelly JL et al. Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Neuropharmacology. 1996;35(9-10):1233-41.

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