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CA-5f
CAS No. 1370032-19-1
CA-5f ( —— )
产品货号. M19958 CAS No. 1370032-19-1
CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥847 | 有现货 |
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| 10MG | ￥1416 | 有现货 |
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| 25MG | ￥2465 | 有现货 |
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| 50MG | ￥3701 | 有现货 |
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| 100MG | ￥5103 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥921 | 有现货 |
|
生物学信息
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产品名称CA-5f
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。
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产品描述CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
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体外实验Cell Viability Assay Cell Line:A549, HUVECs Concentration:20 μM Incubation Time:96 hours Result:Exhibited more cytotoxicity against A549 cells compared with normal HUVECs.Western Blot Analysis Cell Line:A549 cells and HUVECs Concentration:0-40 μM Incubation Time:6 hours Result:Elevated LC3B-II (a marker to monitor autophagy) and SQSTM1 protein levels in a concentration- and time-dependent manner.
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体内实验Animal Model:Nude mice bearing A549 lung cancer cellsDosage:40 mg/kg Administration:Injected via caudal vein, every 2 days for up to 30 days Result:Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice.
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同义词——
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通路Autophagy
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靶点Autophagy
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受体Autophagy
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研究领域——
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适应症——
化学信息
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CAS Number1370032-19-1
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分子量388.46
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分子式C24H24N2O3
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纯度>98% (HPLC)
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溶解度DMSO: 70 mg/mL;Water: Insoluble
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SMILESCOc1ccc(\C=C2/CN(C)C\C(=C/c3c[nH]c4ccccc34)C2=O)cc1OC
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化学全称(3E5E)-3-(34-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhang L et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406.
