Indole-3-pyruvic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indole-3-pyruvic Acid 是一种参与 Indole-3-acetacid 生物合成的化合物，Indole-3-acetacid 是一种植物激素，在调节生长和对环境变化的反应中发挥着重要作用。

Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid a plant hormone which plays important roles in regulating growth and responses to environmental changes.

RT-PCR Cell Line:HaCaT cells Concentration:5-25 mM Incubation Time:6 h Result:Inhibited UVB-stimulated mRNA expression of IL-1β, IL-6, and cyclooxygenase 2 (Cox-2).

Animal Model:BALB/c mice Dosage:Fed in MF chow.0.1% for 5 dAdministration:Oral administration Result:Up-regulated the expression of Cyp1a1 (a biomarker for AHR activation) in the colon.Animal Model:T cell–mediated colitis model of SCID miceDosage:Fed in MF chow.0.1% for 5 wk Administration:Oral administration Result:Suppressed diarrhea and improved colon inflammation.Down-regulated the expression of Th1 and proinflammatory cytokines and upregulated the expression of IL-10 in the colon.Animal Model:HR-1 Hairless Mice Dosage:100 μM Administration:Dose at skin Result:Enhanced the epidermal thickness.Attenuated UVB-induced necrosis observed in upper layer of dermis.

3-(3-Indolyl)-2-oxopropanoic acid

Others

Other Targets

Others

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392-12-1

203.19

C11H9NO3

>98% (HPLC)

DMSO:10 mM

OC(=O)C(=O)Cc1c[nH]c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years