This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process.

Suberosin 具有抗炎和抗凝血活性，还具有针对埃及伊蚊的叮咬威慑活性，可用作杀蚊幼剂。

五味子甲素是从东方药物五味子中提取的主要有效成分，抑制 CYP3A 活性，IC50 为 6.60 μM，Ki 为 5.83 μM。