25-Hydroxycholesterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

25-Hydroxycholesterol 是一种类固醇衍生物，可抑制甾醇调节元件结合蛋白 (SREBP) 的裂解。

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.

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Others

Other Targets

other| HMG-CoA Reductase

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2140-46-7

402.65

C27H46O2

>98% (HPLC)

Ethanol: 20 mg/mL;Chloroform: 50 mg/mL

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

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(-20℃)

With Ice Pack

≥ 2 years