2'3'-cGAMP

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2',3'-cGAMP (2'-3'-环状 GMP-AMP) 是哺乳动物细胞中的内源性 cGAMP。

2'3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2'3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2'3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.2’3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine.Similar to the canonical 3’3’-cGAMP 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β . Structural and functional studies revealed that noncanonical 2’3’-cGAMP is distinct from the canonical 3’3’-cGAMP produced by bacteria [23]. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP.Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP.

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP.

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Immunology/Inflammation

STING

STING

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1441190-66-4

674.41

C??H??N??O??P?

>98% (HPLC)

Soluble in DMSO

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O

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(-20℃)

With Ice Pack

≥ 2 years