Punicalagin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

安石榴苷是石榴中发现的一种主要鞣花单宁，据报道具有抗氧化、抗炎和抗癌作用。

Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.(In Vitro):Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells.Punicalagin slightly inhibits the PLpro activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM.Punicalagin binds at an allosteric site in the dimer interface. Punicalagin inhibit SARS-CoV-2 replication by a mechanism other than preventing S-mediated viral entry.(In Vivo):Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats.

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Others

Other Targets

Others

Others-Field

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65995-63-3

1084.7

C48H28O30

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (92.19 mM)

Oc1c(O)c8c3c2c4c(C(=O)Oc12)c(c(O)c(O)c4OC3=O)c5c(O)c(O)c(O)cc5C(=O)OC[C@H]%10OC(O)[C@@H]%11OC(=O)c6cc(O)c(O)c(O)c6c7c(O)c(O)c(O)cc7C(=O)O[C@H]%11[C@@H]%10OC(=O)c9cc(O)c(O)c(O)c89

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(-20℃)

With Ice Pack

≥ 2 years