Osilodrostat ( LCI699 )

产品货号. M19263 CAS No. 928134-65-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Osilodrostat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Osilodrostat (LCI699) 是人 11β-羟化酶 (IC50: 2.5 nM) 和醛固酮合酶 (IC50: 0.7 nM) 的有效抑制剂。
产品描述

Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
体外实验

——
体内实验

Animal Model:Male Ang-II- and ACTH-stimulated Sprague Dawley rats Dosage:0.1, 0.3, 1 and 3 mg/kg (Ang-II-stimulated rats) and 1, 3, 10, 30 and 100 mg/kg (ACTH-stimulated rats) Administration:Oral administration; once Result:Inhibited the increase in plasma aldosterone concentrations stimulated by Ang II or ACTH in a dose-dependent manner.Animal Model:dTG rats Dosage:3, 10, 30 and 100 mg/kg Administration:Oral administration; daily, for 52 weeks Result:Increased fractional LV (systolic and diastolic) shortening, normalized LV isovolumic relaxation time to RR (IVRT/RR) ratio and myocardial cell size and reduced LV weight in a dose-dependent manner.
同义词

LCI699
通路

Metabolic Enzyme/Protease
靶点

MAO
受体

11β-hydroxylase,aldosterone synthase
研究领域

Endocrinology
适应症

——

1.Li L, et al. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):224-33.

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