Notopterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Notopterol 诱导细胞凋亡并抑制细胞周期特异性。

Notopterol is an analgesic compound with anti-inflammatory action isolated from Notopterygium incisum Ting.

notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner. notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner. Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells. Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP.

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Notopterol

GPCR/G Protein

Histamine Receptor

Others

Others-Field

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88206-46-6

354.4

C21H22O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (282.17 mM)

CC(=CC(CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)O)C

7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((5-hydroxy-3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-

(-20℃)

With Ice Pack

≥ 2 years