Rhynchophylline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

钩藤碱可能通过调节 Akt/mTOR 通路来防止缺血性损伤。

Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

Western Blot Analysis Cell Line:LPS (1 μg/mL) treated N9 cells Concentration:0-30 μM Incubation Time:48 h Result:Inhibited phosphorylated ERK and p38 MAPK level.

Animal Model:Aβ1-42(1.6 μM, 2 μL) treated rats Dosage:100 μM, 2 μL Administration:injected bilaterally in the hippocamp Result:Rescued the soluble Aβ1-42-induced spatial learning and memory deficits.Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs.

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Others

Other Targets

Others

Others-Field

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76-66-4

384.47

C22H28N2O4

>98% (HPLC)

DMSO : 33.33 mg/mL 86.69 mM; H2O : < 0.1 mg/mL

CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

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(-20℃)

With Ice Pack

≥ 2 years