Praeruptorin A (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Praeruptorin A 可以通过抑制 p38/Akt-c-Fos-NFATc1 信号传导和 PLCγ 独立的 Ca(2+) 振荡来发挥其抗破骨细胞活性。

Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

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Metabolic Enzyme/Protease

P450

p38|Akt

Others-Field

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73069-25-7

386.4

C21H22O7

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (258.80 mM)

CC=C(C)C(=O)OC1C(C2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C)OC(=O)C

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(-20℃)

With Ice Pack

≥ 2 years