SKF38393 HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SKF38393 HCl 是一种选择性多巴胺 D1/D5 受体激动剂。

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP.SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.Western Blot Analysis.Cell Line:GC cells Concentration:10 μmol/L Incubation Time:1 hour Result:Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione.SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine. SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline.SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action. Animal Model:Balb/c mice ( 20-25 g).Dosage:5 mg/kg, 10 mg/kg Administration:Intraperitoneal injection Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.

(±)-SKF-38393 hydrochloride | SKF-38393A

Endocrinology/Hormones

AChR

D1| D5 receptor

Neurological Disease

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62717-42-4

291.77

C16H17NO2·HCl

>98% (HPLC)

DMSO : ≥ 34 mg/mL; 116.53 mM

Cl.OC1=C(O)C=C2C(CNCCC2=C1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years