Toosendanin ( —— )

产品货号. M18857 CAS No. 58812-37-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Toosendanin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

川楝素对人早幼粒细胞白血病 HL-6 细胞的生长、细胞周期阻滞、诱导细胞凋亡以及相关信号通路有影响。
产品描述

Toosendanin possesses hepatotoxicity. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. Toosendanin is an effective insecticide for Ae.
体外实验

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体内实验

Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis. Animal Model:Forty-eight male C57BL/6 mice weighing 20-22 g.Dosage:0.5 and 1 mg/kg.Administration:Intraperitoneal injection daily for 7 days.Result:Protected against DSS-induced colitis in mice.Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.
同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

Others-Field
适应症

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CAS Number

58812-37-6
分子量

574.62
分子式

C30H38O11
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (174.03 mM)
SMILES

CC(=O)OC1CC(C23COC(C1(C2CC(C4(C3C(=O)C(C5(C46C(O6)CC5C7=COC=C7)C)OC(=O)C)C)O)C)O)O
化学全称

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