Genistin ( Genistein glucoside | CS-4240 | NSC5112 | NSC-5112 | Genistin )

产品货号. M18741 CAS No. 529-59-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Genistin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

染料木苷是一种天然产物，常见于大豆和豆制品中。
产品描述

Genistin is a selective estrogen receptor modulator (SERM) found in soy. It is the less active glycoside analog of genistein. It acts as a phytoestrogen, induces cell cycle arrest and apoptosis in ovarian cancer cells, improves bone density and strength, and decreases myosin light chain kinase levels.
体外实验

Genistin causes negative regulation of ERα. Genistin also effectively down-modulates ER nuclear translocation as well DNA binding activity in breast cancer cells. Moreover, GS effectively induced apoptosis and suppressed levels of oncogenic markers in MCF-7 cells.
体内实验

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同义词

Genistein glucoside | CS-4240 | NSC5112 | NSC-5112 | Genistin
通路

Membrane Transporter/Ion Channel
靶点

TRP/TRPV Channel
受体

Others
研究领域

Others-Field
适应症

——

CAS Number

529-59-9
分子量

432.37
分子式

C21H20O10
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 43 mg/mL; 99.45 mM
SMILES

c1cc(ccc1c1coc2cc(cc(c2c1=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
化学全称

5-hydroxy-3-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

1. Xiong YJ, et al. Arch Pharm Res. 2013 Mar;36(3):345-52.

计算器

产品手册

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