Gitogenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gitogenin、tigogenin 和 solasodine 是 UGT1A4 的新型选择性抑制剂，并且不抑制主要人类 CYP 亚型的活性。

Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.

When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC50 value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, the IC50 value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC50 value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC50 value of 22.0 μM.

Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) showsrat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).

AI3-62266, Digin, Gitogenin

Others

Other Targets

UGT1A4

Others-Field

——

511-96-6

432.64

C27H44O4

>98% (HPLC)

In Vitro:?DMSO : 1.85 mg/mL (4.28 mM)

CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CC(C(C6)O)O)C)C)C)OC1

5alpha,22alpha-Spirostane-2alpha,3beta-diol

(-20℃)

With Ice Pack

≥ 2 years