Wogonoside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

汉黄芩苷作为 GABAA 受体苯二氮卓位点的正变构调节剂。

Wogonoside is an antifungal agent isolated from Bacopa monnieri.

Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:100 μM Incubation Time:9-24 h Result:Increased the expression of LC3-II and Beclin-1 expression.Inhibited the phosphorylation levels of mTOR at Ser2448 and p70S6K at Ser-389.

Animal Model:MDA-MB-231 orthotopic modelDosage:80 mg/kg Administration:oral gavage, once every other day Result:Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at ?orthotopic site.

Wogonoside | Oroxindin

Cell Cycle/DNA Damage

Topoisomerase

GABA

Cancer|Inflammation/Immunology

——

51059-44-0

460.39

C22H20O11

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (271.51 mM)

COc1c(cc(c2c1oc(cc2=O)c1ccccc1)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O

5,7-Dihydroxy-8-methoxyflavone 7-O-beta-D-Glucuronide

(-20℃)

With Ice Pack

≥ 2 years