Bergaptol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bergaptol 是 CYP3A4 酶脱苄基活性的有效抑制剂。

Bergaptol shows very good radical scavenging activity. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.

Western Blot Analysis Cell Line:LPS-induced RAW264.7 cells Concentration:50 μg/mL Incubation Time:24 h Result:Inhibited JNK phosphorylation and NF-κB activation.Inhibited NF-κB P65 translocation from the cytosol to nucleus.

Animal Model:LPS (40 μg/kg, i.c.v.)-treated miceDosage:10-40 mg/kg Administration:i.p., once a day for two week Result:Reduced LPS-induced fixation and cleavage of neuronal nuclei in the CA1 region of the hippocampus (H&E staining).Increasead the dendritic spine density of mice.Inhibited LPS-induced neuroinflammation.

5-Hydroxypsoralen | 4-Hydroxybergapten

Others

Other Targets

Others

Cancer

——

486-60-2

202.16

C11H6O4

>98% (HPLC)

DMSO : ≥ 50 mg/mL 247.33 mM; H2O : < 0.1 mg/mL

C1=CC(=O)OC2=CC3=C(C=CO3)C(=C21)O

——

(-20℃)

With Ice Pack

≥ 2 years