Pinostilbene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pinostilbene 明显减弱 6-OHDA 引发的 c-Jun 和 JNK 磷酸化。

Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.

Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells.Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells.Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells.Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis.Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Cell Viability Assay Cell Line:HCT116 cells, HT29 cells Concentration:24 hours, 48 hours Incubation Time:0-100 μM Result:Inhibited the growth of two human colon cancer cells.Apoptosis Analysis Cell Line:HCT116 cells, HT29 cells Concentration:20 μM, 40 μM Incubation Time:24 hours, 48 hours Result:Caused a significant and dose-dependent increase in the percentage of cells in S phase.Cell Viability Assay Cell Line:HCT116 cells Concentration:20 μM,40 μM Incubation Time:24 hours, 48 hours Result:Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21Cip1/Waf1, while decreased the expression levels of cyclin E and p-Rb.

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Others

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42438-89-1

242.27

C15H14O3

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (137.57 mM)

COc1cc(cc(c1)O)/C=C/c1ccc(cc1)O

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(-20℃)

With Ice Pack

≥ 2 years