Methyl 4-hydroxycinnamate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Methyl p-coumarate (Methyl 4-hydroxycinnamate)，一种从 Trixis michuacana var longifolia 的花中分离出来的对香豆酸 (pCA) 的酯化衍生物。Methyl p-coumarate 可抑制 B16 小鼠黑素瘤细胞中黑色素的形成。Methyl p-coumarate 对链格孢菌和其他病原体也具有很强的体外抑制作用。

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of?Trixis michuacana?var?longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on?A. alternata?and other pathogens.

Western Blot Analysis Cell Line:Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 1 h)-stimulated A549 cells Concentration:0-100 μM Incubation Time:1 h Result:Inhibited PMA-stimulated phosphorylation of IκBα and p65,as well as c-Jun/c-Fos phosphorylation and c-Jun/c-Fos nuclear translocation.

Animal Model:Ovalbumins (HY-W250978)-induced mice with allergic asthma Dosage:5 mg/kg Administration:p.o.Result:Inhibited the secretion of Th2 cytokines, MCP-1, and IgE.Inhibited eosinophil/macrophage influx.Inhibited immune cell influx and mucus secretion.

——

GPCR/G Protein

Prostaglandin Receptor

Others

——

——

3943-97-3

178.18

C10H10O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (561.23 mM)

COC(=O)/C=C/c1ccc(cc1)O

——

(-20℃)

With Ice Pack

≥ 2 years