Dinoprost Tromethamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) 是一种口服有效的前列腺素 F (PGF) 受体 (FP receptor) 激动剂。Dinoprost tromethamine salt 是在子宫内膜腔上皮和黄体 (CL) 中局部产生的溶酶激素。Dinoprost tromethamine salt 在分娩过程中起关键作用。

Dinoprost Tromethamine, also known as Dinoprost Trometamol, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.(In Vitro):Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells. Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors. Apoptosis Analysis Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:Significantly increased the apoptotic rate (15.62±3.12%).Cell Autophagy Assay Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.Western Blot Analysis Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.

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U 14585 | U14585 | U-14585 | Dinoprost Tromethamine

Others

Other Targets

PEG

Endocrinology

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38562-01-5

475.62

C24H45NO8

>98% (HPLC)

H2O : ≥ 4.8 mg/mL; 10.09 mM

NC(CO)(CO)CO.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

2-amino-2-(hydroxymethyl)propane-1,3-diol (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,Z)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate

(-20℃)

With Ice Pack

≥ 2 years