Jatrorrhizine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Jatrorrizine 是从 Enantia horantha（番荔枝科）和其他物种中分离出的原小檗碱生物碱。

Jatrorrhizine is a AChE inhibitor found in Corydalis and Coptydis. It increases expression of p21 and p27 and induces cell cycle arrest in melanoma cells, suppresses amyloid-β-induced toxicity in neurons, inhibits growth of Plasmodium, Leishmania, and Trypanosoma, and increases gastric emptying rates.

Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC50 values of 3.15 and 82.7 μM, respectively.The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain.Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-, hOCT3-, and PMAT-transfected cells. Jatrorrhizine strongly inhibits PMAT-mediated MPP+ uptake with an IC50 value of 1.05 μM and reduces 5-HT and NE uptake mediated by hOCT2, hOCT3, and hPMAT with IC50 values of 0.1-1 μM (for OCT2 and OCT3) and 1-10 μM (for PMAT).Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1, the common target of current applied antidepressants, is comprised of the serotonin transporter (SERT),the “SERT”, had a high affinity but low capacity to take up [3H]5-HT. Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the “NET”, has low affinity but high capacity to take up [3H]5-HT into brain slices.

Jatrorrhizine (intraperitoneal?injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST). Animal Model:Male ICR albino mice Dosage:5, 10, 20 mg/kg Administration:Intraperitoneal?injection; 5, 10, 20 mg/kg Result:Reduced immobility period in tail suspension test.

Jatrorrhizine

Others

Other Targets

MAO-A| MAO-B

Others-Field

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3621-38-3

338.38

C20H20NO4

>98% (HPLC)

In Vitro:?H2O : 5 mg/mL (14.78 mM)

c1[n+]2c(cc3ccc(c(c13)OC)OC)c1c(CC2)cc(c(c1)OC)O

3-hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium

(-20℃)

With Ice Pack

≥ 2 years