SC-202671

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TCS JNK 5a 是 JNK3(pIC50= 6.7)、JNK2(pIC50=6.5) 的有效、特异性抑制剂。

TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them.

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TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671

Others

Other Targets

JNK2| JNK3

Inflammation/Immunology

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312917-14-9

332.42

C20H16N2OS

>98% (HPLC)

DMSO : ≥ 51 mg/mL; 153.42 mM

C1CCc2c(C1)c(c(s2)NC(=O)c1cccc2ccccc12)C#N

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

(-20℃)

With Ice Pack

≥ 2 years