Ingenol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

巨大戟醇甲丁酯是治疗光化性角化病的有效方法。 2. 从巨大戟二萜醇酯中配制新型衍生物可能是开发新先导化合物以重新激活潜伏 HIV 的创新方法。

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.(In Vitro):Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication.

Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication.

——

Ingenol

Others

Other Targets

Others

Cancer

——

30220-46-3

348.43

C20H28O5

>98% (HPLC)

DMSO : 100 mg/mL 287.00 mM;

CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO

(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one

(-20℃)

With Ice Pack

≥ 2 years