Crocetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Crocetin (Transcrocetin) 从藏红花 (Crocus sativus L.) 中提取的，是一种可透过血脑屏障的，高亲和力的 NMDA 受体拮抗剂。

Croceic acid is a singlet oxygen quencher.(In Vitro):Crocetin, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Crocetin at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability.

Crocetin, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Crocetin at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability.

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trans-Crocetin

Others

Other Targets

Others

Cancer

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27876-94-4

328.4

C20H24O4

>98% (HPLC)

DMSO : ≥ 33 mg/mL; 100.49 mM

CC(=CC=CC=C(C)C=CC=C(C)C(=O)O)C=CC=C(C)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years