Escitalopram Oxalate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Escitalopram Oxalate 是一种选择性血清素 (5-HT) 再摄取抑制剂 (SSRI)，Ki 为 0.89 nM。

Escitalopram Oxalate is a furancarbonitrile that is one of the selective serotonin uptake inhibitors used as an antidepressant. As a selective serotonin reuptake inhibitor (SSRI), escitalopram blocks the reuptake of serotonin by neurons in the central nervous system (CNS), thereby potentiating CNS serotonergic activity. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.

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Animal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:I.p.; daily for 28 days Result:Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.Animal Model:APP-PS1 hemizygous female mice (4 months of age)Dosage:2.5-5 mg/kg Administration:Daily; drinking water for a total of 4 months Result:At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.

Escitalopram Oxalate | Cipralex | Lexapro

Chromatin/Epigenetic

Epigenetic Reader Domain

SSRI

Neurological Disease

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219861-08-2

414.43

C22H23FN2O5

>98% (HPLC)

H2O : ≥ 14.29 mg/mL; 34.48 mM

CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O

(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid

(-20℃)

With Ice Pack

≥ 2 years