Peimisine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

哌咪辛能影响M-受体，兴奋β-受体，抑制体内钙的释放，促进一氧化氮的释放，从而松弛气管平滑肌，缓解哮喘。

Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. Peimisine can attenuate lung tissue injury( ALI), LDH and MDA amount in ALI mice in a dose dependent manner, it also lower the total protein, total white blood cells, lymphocyte and neutrophilic leukocyte in bronchoalveolar lavage fluid( BALF); suggests that peimisine can play a protective role against LPS-induced acute lung injury. Peimisine has the protective effect on the experimental hepatic fibrosis formation, the possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation, and decreasing lipid peroxidation. Peimisine can inhibit angiotensin I converting enzyme activity in a dose-dependent manner, displaying 5 % inhibitory concentration values of 526.5 microM, thus, it may have antihypertensive action.

Peimisine (17.43-92.07 μg/mL; 72 h) shows significant cytotoxic effects.Peimisine (15 μg/mL; 24, 48 and 72 h) induces G0/G1 phase arrest and rising apoptosis rate. Apoptosis Analysis Cell Line:A2780 cells Concentration:15 μg/mL Incubation Time:24, 48 and 72 hours Result:Induced G0/G1 phase arrest of A2780 cells in a time-dependent manner.Cell Cytotoxicity Assay Cell Line:LLC, A2780, HepG2 and A549 cells Concentration:17.43-92.07 μg/mL Incubation Time:72 hours Result:Inhibited LLC, A2780, HepG2 and A549 cells with the IC50 values of 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL, respectively.

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Ebeiensine

GPCR/G Protein

Antibacterial

Others

Others-Field

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19773-24-1

427.62

C27H41NO3

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (29.23 mM)

CC1CC2C(C(C3(O2)CCC4C5CC(=O)C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

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(-20℃)

With Ice Pack

≥ 2 years