Sinapine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

芥子碱是一种来自十字花科植物种子的生物碱，可用作有效的天然化合物来抵抗化疗。

Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. Sinapine has antioxidant and radio-protective activities.

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.

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Others

Other Targets

Antioxidant

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18696-26-9

310.36

C16H24NO5+

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (322.21 mM)

C[N+](C)(C)CCOC(=O)C=CC1=CC(=C(C(=C1)OC)O)OC

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(-20℃)

With Ice Pack

≥ 2 years