Ginkgolide B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ginkgolide B 是从银杏叶中分离得到的 PAFR 拮抗剂 (IC50=3.6 μM)。

Ginkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release.

Western Blot Analysis Cell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24 hResult:Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α.RT-PCRCell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24, 48 h Result:Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.

Animal Model:Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeksDosage:20 mg/kg Administration:Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days Result:Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.

Bilobalide B | Ginkgolide B | BN 52021

Others

Other Targets

PAFR

Others-Field

——

15291-77-7

424.4

C20H24O10

>98% (HPLC)

DMSO : ≥ 30 mg/mL; 70.69 mM

O1[C@H]2[C@@H](O)[C@]34[C@@H]5OC(=O)[C@]3(O[C@@H]3OC(=O)[C@H](O)[C@]43[C@H](C(C)(C)C)C5)[C@@]2(O)[C@H](C)C1=O

5H-Dicyclopenta(b,c)furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-alpha5a,1,2,3,5,8-hexahydroxy-alpha3-methyl-, tri-gamma-lactone

(-20℃)

With Ice Pack

≥ 2 years