SR-12813

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR-12813 是一种孕烷 X 受体 (PXR) 激动剂。

SR-12813 is a pregnane X receptor (PXR) agonist.

SR-12813 inhibits incorporation of tritiated water into cholesterol with an IC50 of 1.2 μM but has no effect on fatty acid synthesis. Furthermore, SR-12813 reduces cellular 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity with an IC50 of 0.85 μM. Both 25-HC and SR-12813 can kill mammalian cells through blocking the synthesis of cholesterol, thereby they are ideal regents for lethal selection. SR-12813 kills HeLa cells at concentration range from 8 μM to 16 μM. SR-12813 kills wild type cells and mutant cells infected by Ad-Cre (SL-5+Cre), but the mutant SL-5 survives this condition. SR-12813 or 25-HC promotes the degradation of the 95-KDa full-length HMG-CoA reductase in wild type HeLa and SL-5 mutant cells.

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GW 485801

Membrane Transporter/Ion Channel

Carbonic Anhydrase

HMG-CoA reductase

Metabolic Disease

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126411-39-0

504.53

C24H42O7P2

>98% (HPLC)

DMSO : ≥ 50 mg/mL; 99.10 mM

CCOP(=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)P(=O)(OCC)OCC

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(-20℃)

With Ice Pack

≥ 2 years